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REVIEW ARTICLE
Year : 2021  |  Volume : 4  |  Issue : 1  |  Page : 13-20

Innovations in drug-device combinations for delivering medication to the airways


Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India

Correspondence Address:
Dr. Jyothsna Manikkath
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576 104, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/arwy.arwy_15_21

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Airway drug delivery is an effective mode of delivery of drugs for local action in the respiratory tract or for producing faster systemic effect of drugs that have poor oral bioavailability. However, pulmonary drug delivery is incredibly challenging. This article discusses the various types of drug delivery devices, their advantages and limitations. Drugs for pulmonary delivery are typically aerosolised using devices such as pressurised metered-dose inhalers, dry powder inhalers (DPIs), nebulisers, soft-mist inhalers (SMIs) and their variants. The efficiency of drug therapy is influenced both by the drug formulation and the drug-device combination. Further, efficacy of the inhaler and its correct use by the patient are critical issues. Besides the drug component, the incorporation of propellants and other adjuvants in the formulation has been analysed from the perspectives of patient safety and environmental pollution. These devices have evolved with time bringing the advances in technology for use. Feedback mechanisms and particle engineering have been tried and tested.


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